Lewes, DE vs Millsboro, DE

The cost of living difference between Lewes, DE and Millsboro, DE is dramatic. Millsboro is 46.1% cheaper than Lewes, a gap that translates to thousands of dollars per year in household expenses. Lewes has a cost index of 139 while Millsboro sits at 95, making this one of the more striking comparisons on our site. Relocating between these cities would require a serious reassessment of budget and lifestyle expectations.

On the housing front, median rent in Lewes is $1,271/month compared to $1,207/month in Millsboro — a 5% difference. Home values follow the same pattern: Millsboro is more affordable at $297,000 median vs $806,700.

Median household income in Lewes is $92,375 compared to $77,750 in Millsboro (+18.8%). Lewes does offer higher incomes, but the salary premium barely offsets the higher cost of living, leaving residents with a tighter budget. Looking at affordability, residents of Lewes spend roughly 16.5% of their income on rent, less than the 18.6% in Millsboro.